Table 1.
Baseline MAP and HR before and after the administration of DAMGO, saline, and naloxone with DAMGO
| n | MAP, mmHg | HR, beats/min | |
|---|---|---|---|
| Freely perfused group | |||
| Intra-arterial administration (DAMGO treatment) | |||
| Control | 8 | 90.4 ± 6.7 | 436.4 ± 14.4 |
| DAMGO | 8 | 8.14 ± 3.8 | 444.5 ± 16.5 |
| Intravenous adminstration | |||
| Control | 6 | 73.6 ± 11.1 | 470.7 ± 25.8 |
| DAMGO | 6 | 76.3 ± 11.3 | 476.1 ± 17.9 |
| Intra-arterial adminstration (saline treatment) | |||
| Control | 6 | 79.8 ± 4.6 | 491.3 ± 18.4 |
| Saline | 6 | 74.8 ± 2.4 | 493.8 ± 15.3 |
| 72-h occluded group | |||
| Intra-arterial administration (DAMGO treatment) | |||
| Control | 10 | 89.7 ± 4.7 | 404.1 ± 9.0 |
| DAMGO | 10 | 92.7 ± 1.7 | 396.6 ± 10.0 |
| Intravenous administration | |||
| Control | 6 | 87.6 ± 4.6 | 421.5 ± 10.5 |
| DAMGO | 6 | 86.0 ± 5.0 | 410.4 ± 6.9 |
| Intra-arterial administration (saline treatment) | |||
| Control | 6 | 86.1 ± 2.4 | 392.2 ± 16.3 |
| Saline | 6 | 86.2 ± 5.0 | 400.3 ± 13.6 |
| Intra-arterial administration (DAMGO + naloxone treatment) | |||
| Control | 7 | 77.5 ± 4.3 | 406.8 ± 10.0 |
| Naloxone and DAMGO | 7 | 85.6 ± 5.3 | 411.6 ± 12.9 |
Values are means ± SE; n, no. of rats/group. MAP, mean arterial pressure; HR, heart rate; DAMGO, [d-Ala2,N-MePhe4,Gly-ol5]enkephalin; freely perfused group, control rats whose hindlimb was freely perfused; 72-h occluded group, rats whose femoral artery had been ligated 72 h before the start of the experiment.