Fig. 2.
Effect of exposure to reduced O2 tension on ATP release from erythrocytes of healthy humans (n = 11; A) and humans with type 2 diabetes (DM2; n = 10; B). In a tonometer, isolated erythrocytes (20% hematocrit) were exposed to gas mixtures containing, sequentially, 15% O2, 6% CO2, balance nitrogen, 4.5% O2, 6% CO2, balance nitrogen and 0% O2, 6% CO2, balance nitrogen. ATP release was determined 30 min after exposure to 15% O2 and 10 min after exposure to 4.5 or 0% O2. Values are means ± SE. *Greater than respective 15% O2 value (P < 0.05). †Greater than respective 15% O2 value (P < 0.01) and respective 4.5% O2 value (P < 0.05). Po2, Oxygen tension of the blood in the tonometer.