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Stimulation of β1-AR but not β2-AR induces cell apoptosis. (A) Representative micrographs show TUNEL staining in myocytes infected by adeno-β1-AR or adeno-β2-AR and treated with ISO. Apoptotic nuclei appear blue by TUNEL staining with a varying degree of condensation of nuclear chromatin (arrows). (B and C) The average data of TUNEL and Hoechst staining. *, P < 0.01 versus untreated or uninfected myocytes and those infected by adeno-β2-AR (n = 5 to 6 for each group).
