Skip to main content
. 2010 Aug 3;107(33):14857–14862. doi: 10.1073/pnas.1009532107

Fig. 3.

Fig. 3.

The impaired analgesia in α1G−/− and PAG-specific α1G-knockdown mice. (A and B) Bar graphs for the effects of α1G T-type channels in pain sensation. The wild-type and α1G−/− mice as well as the scrambled shRNA and shRNA-α1G mice showed similar basal thermal sensitivity (A). The SSIA was impaired in α1G−/− (17.71% ± 1.98% and 8.44% ± 1.74% analgesia for wild-type and mutant mice, respectively) and α1G-knockdown mice (22.48% ± 2.68% and 14.70% ± 1.66% analgesia for scrambled and shRNA-α1G mice, respectively) (B). (C–F) Time course for the effects of morphine or saline at the systemic level (C and D) and the PAG level (E and F). (G and H) The percent analgesia at 60 min postinfusion from C and D are shown in G, whereas those at 30 min postinfusion from E and F are shown in H.