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The reversed opioidergic analgesia by antagonizing local GABAA receptors in the vlPAG of α1G−/− mice. (A–C) The analgesic effects of morphine with or without bicuculline in the vlPAG of wild-type (A) and mutant mice (B). In mutant mice, the mixture induced a nearly complete restoration of analgesia to the wild-type levels. RM ANOVA and posthoc Tukey test. (C) The percent analgesia at 15 min postinfusion from A and B.
