Fig. 4.

Basal locomotor activity is altered in DARPP-32 conditional KO mice. Locomotor activity was measured by placing mice individually into an open-field chamber and recording the distance traveled. (A and C) Line graphs showing the distance traveled (in centimeters) in 3-min bins over a 60-min period by mice of the indicated genotypes. (B and D) Bar graphs showing the average total distance traveled (in centimeters) over the 60-min test period. n = 16–25 mice per genotype. Data are expressed as mean ± SEM. **P < 0.01; ***P < 0.001, unpaired two-tailed t test.