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Vorinostat can suppress expression of DNA DSB repair proteins in transformed, but not normal, cells. Cells were cultured with 5 μM vorinostat for indicated times. Immunoblots were probed with antibodies as described in Materials and Methods. DNA damage repair proteins assayed: RAD50, MRE11, 53BP1, KAP1, TIP60, p-ATM, and ATM.
