. Author manuscript; available in PMC: 2010 Aug 31.

Published in final edited form as: N Engl J Med. 2009 Aug 6;361(6):569–579. doi: 10.1056/NEJMoa0900563

Table 2.

Treatment Comparisons on Primary Outcomes (Intent-to-Treat analyses).

Primary Outcome Measures	Vertebroplasty	Control	Treatment Comparison (95% CI)^§	P-value^§
Primary Outcome Measures	M (SD)	M (SD)	Treatment Comparison (95% CI)^§	P-value^§
RDQ^*
Baseline	16.6 (3.8)	17.5 (4.1)
3 Days	13.0 (5.2)	12.5 (5.5)	−0.9 (−2.7, 0.8)	0.30
14 Days	12.4 (5.8)	12.3 (5.9)	−0.6 (−2.4, 1.2)	0.35
1 Month	12.0 (6.3)	13.0 (6.4)	0.7 (−1.3, 2.8)	0.49
Average Pain Intensity^†
Baseline	6.9 (2.0)	7.2 (1.8)
3 Days	4.2 (2.8)	3.9 (2.9)	−0.4 (−1.5, 0.5)	0.37
14 Days	4.3 (2.9)	4.5 (2.8)	0.1 (−0.8, 1.1)	0.77
1 Month	3.9 (2.9)	4.6 (3.0)	0.7 (−0.3, 1.7)	0.19

RDQ ranges from 0 to 23 with higher scores indicating worse physical disability.

^†

Average Pain Intensity ranges from 0 = ‘no pain’ to 10 = ‘pain as bad as could be’.

^§

Treatment comparisons, confidence intervals and P-values are calculated from ANCOVA models that adjust for randomized treatment assignment, the baseline value of the outcome measure, and recruitment site. Negative treatment effects favor the control procedure and positive treatment effects favor vertebroplasty.