Skip to main content
. Author manuscript; available in PMC: 2011 Sep 15.
Published in final edited form as: Bioorg Med Chem Lett. 2010 Jul 30;20(18):5411–5413. doi: 10.1016/j.bmcl.2010.07.103

Figure 2.

Figure 2

Compounds 1 (panel A) and 2 (panel B) block LPS-induced TLR4 activation in macrophages. LPS was added to murine macrophages to a final concentration of 2 ng/mL, in the presence or absence of 2 μM 1 or 200 nM 2. If no visual response was observed after an additional 2.5 minutes, 25 ng/mL C5a (an Akt signaling agonist via a non-TLR4 pathway) was added to confirm that the cells were still responsive.[30] Data are means from ten independent experiments; error bars show s.e.m.