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Anticonvulsant effect of CYM2503 in the Li-pilocarpine model in rats. (A) Latency to first EEG seizure and latency to first stage 3 or higher behavioral seizure. (B) Latency to the establishment of SE. Data are mean ± SEM. (*P < 0.05 and **P < 0.01, ANOVA followed by Dunnett multiple comparison vs. respective controls, n = 4–5.) LEV, levetiracetam 50 mg/kg i.p. CYM2503 dose was 60 mg/kg i.p.
