Fig. 4.

Analysis of cellular immune responses in three chimpanzees belonging to an experimentally infected HIV-1 cohort. The peptides present in the Gag peptide pools are summarized in Fig. S4. A plus sign indicates that a CTL response to the Gag pool was observed, and the percentage-specific lysis is given in brackets (31). The Patr-A and -B molecules present on the haplotypes of chimpanzees Laurens, Zeef, and Thijs are given. The relevant MHC/peptide combinations that probably contribute to the previously observed Gag-pool-specific CTL responses are given, and the color codes of the peptides correspond to the colors in Fig. 2. Previously described CTL epitopes are underscored (30). A gray background indicates data obtained using only the NetMHCpan 2.0 algorithm. ^aAnimal is homozygous for this molecule.