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. 2010 Aug 9;107(34):15081–15086. doi: 10.1073/pnas.1009575107

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Fig. 5. — ERα-positive breast cancer patients with tumors expressing wild-type p53 respond better to tamoxifen therapy. (A) Kaplan-Meier analysis of the overall survival of 35 ERα-positive (28 patients had tumors with wild-type p53 and 7 patients had tumors with mutant p53), tamoxifen-treated breast cancer patients as a function of wild-type or mutant p53 expression. (B) Similar analysis as in A of 36 ERα-negative breast cancer patients (17 patients had tumors with wild-type p53 and 19 patients had tumors with mutant p53) who were not treated with tamoxifen. (C) A model for the role of the ERα–p53 interaction in tumor response to antiestrogen therapy.