TNF incubation resulted in significant FM weakening that was not inhibited by pretreatment with Vitamin C. Rupture Force for four treatment groups are displayed: Control, Vitamin C pre-treatment, TNF, Vitamin C followed by TNF (see Methods for details). Data points represent pooled results of six experiments using three FM fragments per treatment group in each experiment (N=18). Data are presented as mean ± SD. (* p=.04, + p=.02, ++ p=.86)