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. Author manuscript; available in PMC: 2010 Aug 31.
Published in final edited form as: Biopolymers. 2008 Jul;89(7):565–577. doi: 10.1002/bip.20961

FIGURE 5.

FIGURE 5

Single-molecule FRET studies resulted in a new model of tRNA dynamics on the ribosome. The large activation energies associated with transitions between tRNA hybrid states indicate that these transitions are coupled to large-scale conformational rearrangements of the ribosome. A key observation was that tRNA can move independently on the ribosome. The motions of each tRNA appear to be governed by distinct conformational changes of the ribosome as indicated by the coloration of the ribosomal domains.