Fig. 8. Point Mutations in the −1636/−1631 CAATTA Repeat Decrease Transcriptional Activity.
A, The results of transient transfections utilizing enhancers with a single point (−1633c) or a double point (−1635c/−1632 g) mutation in the −1636/−1631 CAATTA repeat are presented. A diagram of the plasmid is shown above the bar graphs. B, The activities of enhancers containing these same mutations on the RSV promoter are shown. Transfections are as in Fig. 1B. Stars indicate a statistically significant decrease from wild-type values, as determined by a one-way ANOVA (P < 0.05).