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. 2010 Aug 13;11:97. doi: 10.1186/1471-2202-11-97

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Copyright ©2010 Saggu et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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TEM of distal segment of rat optic nerve after 7 days of NMDA injection. Transverse (A, Bar = 20 μm & B, Bar = 5 μm) and longitudinal sections (C, Bar = 20 μm & D = Bar = 5 μm) show the fibres undergoing dark degeneration with most axons showing hyperdense axoplasm (red arrows). Longitudinal profile show the focal axonal swelling and hyperdense axoplasm in the same axon (D, arrows). Axon towards the end stage of degeneration (E, Bar = 1 μm) show nearly collapsed axon structure and the myelin debris phagocytosed by the astrocytes (F, Bar = 5 μm). Last series of photographs (G1, G2, G3, Bar = 2 μm) represent axoplasm in various stages of dissolution.