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Design of TRPM2/TRPM8 channel chimeras. The presumed basic structure of TRP channels, including the exchanged S5-pore-S6 domain (gray shading), is illustrated. The corresponding amino acid sequences of TRPM2 and TRPM8 are shown in single-letter code, and conserved residues are shown in boldface. The site within S6 where the exchange of a hydrophobic residue with a lysine reverses the charge selectivity of the pore in both TRPM2 and TRPM8 is marked with an asterisk (19).
