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. 2010 Jun 29;285(35):26806–26814. doi: 10.1074/jbc.M110.109975

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© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 6. — Behavior of M2-M8P at far-negative potentials. A, current-voltage relation of M2-M8P and TRPM2 obtained with voltage ramps from −150 to +150 mV. B and C, increased closed times of M2-M8P at strong hyperpolarization. B shows characteristic traces from TRPM2 (upper) and M2-M8P (lower) during activation by ADPR (0.1 mm in 1 μm Ca²⁺). After the opening of several channels, the holding potential was changed from −60 to −120 mV. C shows the effects of hyperpolarization to −150 mV of ADPR-activated M2-M8P at two different time scales.