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MDM2-mediated ATF3 degradation requires the binding of MDM2 to ATF3. A, H1299 cells were transfected with the indicated plasmids and subjected to IP using the ATF3 antibody. B, ATF3 or Δ80–100 was expressed with or without MDM2 and subjected to immunoblotting as in Fig. 3A. C, schematic representation of negative-feedback loops for tight controls of p53 activity in cellular stress responses is shown.
