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. 2010 Jun 21;285(35):26945–26955. doi: 10.1074/jbc.M110.151803

FIGURE 3.

FIGURE 3.

Effect of the Liddle mutation on airway Na+ absorption in CFTR-deficient mice. A–C, in vivo measurements of basal and amiloride-sensitive nasal PD (A) and ex vivo measurements of basal and amiloride-sensitive Isc in nasal tissues (B) and tracheal tissues (C) from WT mice, L/L mice, single mutant CFTR-deficient (CF) mice, and double mutant CFTR-deficient Liddle (CF + L/L) mice. A, nasal PD measurements. n = 8–12 mice/group. *, p < 0.001 compared with WT and L/L mice; †, p < 0.001 compared with WT, L/L, and CF mice. B, nasal Isc measurements. n = 5–7 mice/group. *, p < 0.05 compared with WT and L/L mice; †, p < 0.02 compared with L/L mice; ‡, p < 0.01 compared with WT and L/L mice; §, p < 0.05 compared with CF mice. C, tracheal Isc measurements. n = 6–9 mice/group. *, p < 0.05 compared with WT mice; †, p < 0.01 compared with L/L mice. ‡, p ≤ 0.02 compared with CF mice; §, p < 0.001 compared with WT and CF mice. Error bars, S.E.