FIGURE 3.

A, stereo ribbon diagram of human F508del-NBD1 structure (Protein Data Bank code 2BBT) revealing the positions of Leu⁵⁸¹ and Lys⁵⁸⁴ (highlighted by the square). The LSGGQ motif and the Walker B motif are also shown (black ribbon and arrow, respectively). B, close-up view of the same structure as in A (human NBD1) in the vicinity of Lys⁵⁸⁴ (dark gray) showing the interaction of its side chain with that of Leu⁵⁸¹ (dark gray). C, similar close-up view but in the mouse NBD1 structure (Protein Data Bank code 1RXO) showing the interaction between the side chains of the corresponding mouse residues, namely Glu⁵⁸⁴ and Phe⁵⁸¹ (both in dark gray). In B and C, the side chains of residues 581 and 584 are shown (dark gray).