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. 2010 Jun 15;285(35):27033–27044. doi: 10.1074/jbc.M110.120352

TABLE 1.

Summary information of CFTR point mutants analyzed in present study

CFTR variants Clinical dataa Band C/band Bb (±S.E., n = 5) Processingc Normalized processingd Normalized iodide efflux functione (±S.E., n = 6) Iodide efflux to processed proteinf
% % % % peak intensity %
WT-CFTR g 83 ± 3 77 100 100 ± 8
Murine 86 ± 5 66 86 74 ± 4 86 ± 4
E527Q Mild CF 64 ± 5 49 63 46 ± 4 73 ± 4
E528Q 86 ± 5 79 102 135 ± 16 132 ± 10
S531T 87 ± 6 81 105 71 ± 5 67 ± 5
K536Q 69 ± 3 42 54 51 ± 4 94 ± 3
I539T Revertant 112 ± 5 81 105 49 ± 6 46 ± 5
L581F 118 ± 3 83 107 72 ± 5 67 ± 3
L581F/K584E 125 ± 2 77 100 100 ± 12 100 ± 8
T1263I Mild CF 75 ± 3 76 98 31 ± 8 31 ± 5
P1290T Asymptomatic 87 ± 3 82 106 92 ± 10 86 ± 6
K1302Q 72 ± 3 77 100 37 ± 2 37 ± 2
Y1307N 82 ± 2 76 98 70 ± 5 71 ± 3
Q1309K 79 ± 4 77 100 26 ± 2 26 ± 3
S1311K 73 ± 4 72 93 33 ± 7 35 ± 5
R1325K 64 ± 6 78 101 47 ± 2 46 ± 4
V1338T 88 ± 2 77 100 37 ± 11 37 ± 6
C1344Y 71 ± 4 76 98 86 ± 4 87 ± 4
L1367I 72 ± 5 80 103 36 ± 5 34 ± 5
D1394G 78 ± 4 86 111 93 ± 12 83 ± 8
E1409D 70 ± 3 70 90 43 ± 5 47 ± 4

a Data from the CFTR mutation database.

b Percentage of processing given by (band C/band B) × 100.

c Percentage of processing given by (band C/(band B + band C) × 100).

d Ratio of the “percent band C” value for each mutant (from previous column) over the same “percentage for WT-CFTR.”

e Iodide efflux expressed as percentage of peak intensity relative to that of WT-CFTR.

f Ratio of “Normalized iodide efflux function” values (from previous column) normalized to “Normalized processing” values (from column 5).

g —, not applicable/no information.