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Inhibition of PKG prevents 17β-estradiol-mediated Ca2+ efflux stimulation. Ca2+ efflux from populations of intact rat hepatocytes was measured at 37 °C using fura-2 in the extracellular medium. The traces shown in A–C are representative of several experiments. 10 nm 17β-estradiol (water-soluble), 25 μm Rp-8-pCPT-cGMPS (Rp), and 4 μm DT-3 were added where indicated by the arrows. Calculated rates of Ca2+ efflux are shown in D. *, significantly different from control.
