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Lactacystin prevents degradation of both mature hERG and Cav1 under 0 mm K+ conditions. A, hERG and Cav1 expression levels in hERG-HEK cells cultured in 5 mm K+ MEM, 0 mm K+ MEM, or 0 mm K+ MEM with 20 μm lactacystin for 3 or 6 h. B, expression levels of the S624T hERG mutant channel and Cav1 in cells cultured in 5 or 0 mm K+ MEM for 3 or 6 h.
