FIGURE 5.

Stereoview of one of the possible CoA-binding sites of ATP-citrate lyase superposed on the CoA-binding site of E. coli succinyl-CoA synthetase. Stick models are shown for CoA bound to E. coli succinyl-CoA synthetase, for the phosphohistidine residue and for residues of this protein with atoms within 3.6 Å of CoA. These stick models are colored according to atom type: phosphorus in light green, sulfur in magenta, oxygen in red, nitrogen in blue, and carbon in gray. The residues labeled are in the α-subunit of E. coli succinyl-CoA synthetase. Residues of truncated human ATP-citrate lyase that lie in similar positions are shown by stick models for their side chains. The coloring is similar to that used for E. coli succinyl-CoA synthetase, but the carbon atoms are shown in cyan. In addition, citrate is shown as a magenta stick model and parts of ATP-citrate lyase lying within the view are displayed as cyan and yellow ribbon diagrams, as in Fig. 2.