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The relationship between different free energy changes for the reactions catalyzed by two enzymes. E(i) is the free enzyme, ES(i) represents the enzyme-substrate complex, and TS1(i) refers to the transition state. ΔG(i) is the sum of the enzyme-substrate binding free energy ΔGES(i) and the activation free energy ΔGav(i) (i = 1, 2).
