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. Author manuscript; available in PMC: 2010 Aug 31.
Published in final edited form as: Angew Chem Int Ed Engl. 2009;48(34):6257–6261. doi: 10.1002/anie.200901209

Figure 4.

Figure 4

13C-13C couplings (or in some instances the absence of coupling) observed in 13C (a) and 2D-INADEQUATE (b) NMR spectra of [1,2-13C]acetate labelled erdacin indicate that two distinct polyketide cyclization patterns are used in the biosynthesis of erdacin. Couplings between weak or overlapping NMR signals not clearly seen by 2D-INADEQUATE were inferred based on polyketide biosynthetic precedent. The exact structure of the late stage polyketide intermediates used in the biosynthesis of erdacin is not known.