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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Curr Opin Pharmacol. 2010 Jun 4;10(4):362–368. doi: 10.1016/j.coph.2010.05.003

Table 1.

Carcinoma and Evaluated Redox State Marker of Oxidative Stress Detection Method Reference
Extracellular Prostate ↑ H2O2; ↑ GSH/↓ GSSG; ↑ EC-SOD Dihydroxyphenoxazine fluorescence; 5.5′-dithiobis - (2-nitrobenzoic acid)-GSSG recycling; Western blot [18]
Hepatocellular ↑ Thioredoxin ELISA [45]
Pancreatic ↑ Thioredoxin ELISA [46]
Liver Metastasis ↑ Hydroxyl Radicals, ↑ H2O2, ↑ Superoxide anions Electron spin resonance spectrometry [47]
Colon Thiol/disulfide balance HPLC detection of N,N bis-dansyl or S- carboxymethyl-N-dansyl derivatives with fluorescence detection [20]
Lymphoma ↑ Glutathione S-transeferase P ELISA [48]
Breast, Gastric. Colorectal ↓ Glutathione peroxidase 3 activity Absorbance assay based on reduction of GSH to GSSG [49]
Intracellular Pancreatic ↑ Thioredoxin, ↑ Glutaredoxin Immunohistochemistry [46]
Squamous ↑ γ-glutamyltransferase Immunohistochemistry [50]
Ovarian, Lung, Breast, Colon, Pancreas, Lymphoma ↑ Glutathione S-transeferase P RT-PCR; Immunohistochemistry Western blot [51]
Breast ↑ Thioredoxin, ↑ Peroxiredoxins RT-PCR; Western blot [52]
Ovarian, Prostate Melanoma, Colon, Pancreatic, Neuroblastoma, Breast, Ovarian ↑ H2O2 CM2-DCFHDA staining [53]
↑ H2O2 Horseradish peroxidase-assay using hydrogen donors [54]