Table 4. Changes in sensitivity and specificity, total change and change in F1 score when threshold relaxation is applied.

Methods	Sensitivity	Specificity	Total
SPMap	20.80	−9.94	10.86	0.14
BLAST-kNN	4.13	−3.44	0.69	−0.10
Pepstats-SVM	62.66	−21.17	41.49	0.26
Voting	21.68	−5.86	15.82	−0.14
Mean	24.02	−4.95	19.07	−0.13
Weighted Mean	15.56	−3.96	11.60	−0.14
Addition	25.63	−6.19	19.44	−0.05

A positive value indicates an increase whereas a negative value indicates a decrease.