Table 4.
DAS28 response data by genotype and association p values for three successfully genotyped SNPs in 1334 individuals
| First and additional cohorts combined (n=1334) | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Additive model | Dominant model | ||||||||||||||||||
| SNP | Gene | Chr | bp | Genotype | Count | Mean baseline DAS28 | SD baseline DAS28 | Mean change in DAS28 | SD change in DAS28 | HWE exact p value | Genotypic global p value | Global p value | Coef | Min 95 | Max 95 | Global p value | Coef | Min 95 | Max 95 |
| rs10865035 | AFF3 | 2 | 100202166 | AA | 320 | 6.66 | 1.01 | −2.30 | 1.51 | 0.228 | 0.036 | 0.015 | −0.14 | −0.25 | −0.03 | 0.013 | −0.23 | −0.41 | −0.05 |
| AG | 688 | 6.65 | 0.97 | −2.51 | 1.49 | ||||||||||||||
| GG | 323 | 6.66 | 0.98 | −2.59 | 1.57 | ||||||||||||||
| rs7574865 | STAT4 | 2 | 191672878 | GG | 738 | 6.69 | 0.97 | −2.56 | 1.51 | 0.469 | 0.173 | 0.203 | 0.08 | −0.04 | 0.21 | 0.091 | 0.13 | −0.02 | 0.29 |
| GT | 514 | 6.64 | 0.98 | −2.38 | 1.56 | ||||||||||||||
| TT | 80 | 6.50 | 1.08 | −2.42 | 1.36 | ||||||||||||||
| rs763361 | CD226 | 18 | 65682622 | TT | 359 | 6.62 | 1.01 | −2.60 | 1.44 | 0.622 | 0.141 | 0.048 | 0.11 | 0.00 | 0.22 | 0.098 | 0.15 | −0.03 | 0.32 |
| TC | 657 | 6.65 | 0.95 | −2.48 | 1.56 | ||||||||||||||
| CC | 318 | 6.69 | 1.03 | −2.36 | 1.51 | ||||||||||||||
Significant p values (<0.05) are shown in bold type, italic indicates p<0.10.
bp, base pairs; Chr, chromosome; Coef, coefficient for minor allele (except at rs10865035); DAS, disease activity score; HWE, Hardy–Weinberg equilibrium; SNP, single nucleotide polymorphism.