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. 2010 Aug 31;5(8):e12473. doi: 10.1371/journal.pone.0012473

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Inaba et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Definition of GSC centrosome orientation. GSCs were scored as misoriented when neither of the two centrosomes was juxtaposed to the hub-GSC interface. (B) Examples of GSCs with misoriented centrosomes (arrowheads) upon expression of E-cad^dCR4h. γ-tubulin (centrosomes). (C) Examples of GSCs with oriented centrosomes (arrows) upon expression of E-cad^DEFL (D) Quantification of GSC centrosome misorientation upon expression of E-cad^dCR4h or E-cad^DEFL. Siblings without the nos-gal4 driver from the same cross served as controls. n>300 GSCs per data point. (E) An example of a dedifferentiating spermatogonium observed in testis expressing E-cad^dCR4h. Multiple germs cells (including one attached to the hub) is connected by disintegrating ring canals and fusomes (arrowheads). Pavarotti-GFP marks ring canals, and Adducin-like marks fusome. (F) Quantification of dedifferentiation upon expression of E-cad^dCR4h or E-cad^DEFL. Siblings without the nos-gal4 driver from the same cross served as controls. n>700 GSCs per data point.