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. 2010 Aug 31;5(8):e12490. doi: 10.1371/journal.pone.0012490

Figure 3. MINO plus NAC synergistically improved active place avoidance during spaced training that requires 24-hour memory.

Figure 3

Panel A, Experimental Design. Rats received moderate CCI or sham-injury. Saline or drug treatments were administered 1 hour, 1 day and 2 days after injury. Beginning 8 days after injury, rats received spaced training of active place avoidance consisting of a 20-minute trial each day for 15 days. Panel B, The number of entrances into the shock zone measured overall avoidance learning. Panel C, Time to 1st entrance into the shock zone measured learning that depended on 24-hour retention. These data suggest that long-term memory was improved by MINO plus NAC but not MINO. MINO plus NAC acted synergistically since the improvement in time to enter the shock zone occurred only with co-administration of both drugs.