TABLE 3.

Prospective Randomized Trials on Laparoscopic versus Open Surgery for Colon Cancer

Reference	Study	Resection Type	Exclusion	n	Technique	Operating time (min)	Morbidity	Mortality	Lymph nodes (n)	Median Follow-up (months)	Recurrence	Overall 3-Year Survival
Veldkamp et al9 Buunen et al16	COLOR	Right Side Left Side Sigmoid Other	BMI > 30 kg/m2 Transverse Splenic Flexure Metastasis Intestinal Obstrruction Multiple Primary Tumors Synchronous Abdominal Surgery Organ Invasion Previous Colon Surgery Previous Malignancy	551	open	115 *	20.0%	2%	10	53	17.0%	84.2%
				544	laparoscopy assisted	145 *	21.0%	1%	10		19.7%	81.8%
Lacy et al10,14	Barcelona Trial	Right Side Left Side Sigmoid Anterior Resection Subtotal Colectomy Hartmann Procedure	Transverse Metastasis Organ Invasion Intestinal Obstruction Previous Colon Surgery	102	open	118 *	28.7% *	2.9%	11.1	95	28.0%	~82%
				106	laparoscopy assisted	142 *	10.8% *	<1%	11.1		18.0%	~86%
Clinical Outcomes of Surgical Therapy Study Group8	COSTSG	Right Side Left Side Sigmoid	Transverse Rectal Metastasis Emergency	428	open	95 *	20.0%	1%	12	53	19.6%	~85%
				435	laparoscopy assisted	150 *	21.0%	<1%	12		17.5%	~85%
Guillou et al11 Jayne et al15	CLASICC	Right Side Left Side Sigmoid Anterior Resection Abdominoperineal Resection	Transverse Intestinal Obstruction Previous Malignancy Multiple Primary Tumors Pregnancy Other GI Disease	253	open	_	42.0%	5%	13.5	36.8	22.2%	66.7%
				484	laparoscopy assisted	_	47.0%	4%	12		23.8%	68.4%

^*significant in original publication