FIG. 1.

Body-weight changes (A) and daily food intake (B) in vehicle-fed SHROB rats and SHROB rats fed captopril or allylmercaptocaptopril. (A) Body weights are shown as percent change from baseline. Baseline body weights were 490 ± 17 SEM g for controls, 488 ± 13 SEM g for the captopril group, and 510 ± 26 SEM g for the allylmercaptocaptopril group. Two-way analysis of variance with repeated measures on body weight indicated a main effect of time (F = 8.8, P < .01) and a significant interaction between time and drug (F = 1.7, P = .02). (B) Food intake is shown in grams per day per animal. There were no changes over time and no differences between groups by two-way analysis of variance with repeated measures.