Table 3.

Multivariate analysis

	Disease-specific survival			Overall survival
	HR	95% CI	P-value	HR	95% CI	P-value
Age	1.01	1.01–1.01	<0.001	1.02	1.01–1.02	<0.001
Tumor size   (mm)	1.00	1.00–1.00	<0.001	1.00	1.00–1.00	<0.001
# ALN   metastasis	1.02	1.02–1.03	<0.001	1.02	1.01–1.02	<0.001
ER status
Positive			Referent
Negative	1.84	1.67–2.02	<0.001	1.71	1.57–1.86	<0.001
Borderline	1.45	1.06–1.97	<0.02	1.28	0.96–1.70	<0.10
Unknown	1.62	1.25–2.10	<0.001	1.62	1.29–2.05	<0.001
PR status
Positive			Referent
Negative	1.35	1.23–1.48	<0.001	1.31	1.21–1.42	<0.001
Borderline	1.92	1.44–2.56	<0.001	1.71	1.30–2.23	<0.001
Unknown	0.91	0.71–1.18	<0.50	0.84	0.67–1.06	<0.15
Radiation
No			Referent
Yes	0.79	0.74–0.84	<0.001	0.76	0.72–0.81	<0.001
Anthracycline era
Pre-AE			Referent
Post-AE	0.84	0.79–0.91	<0.001	0.90	0.84–0.96	0.001