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. 2010 Apr 7;95(9):1599–1603. doi: 10.3324/haematol.2010.023325

Figure 1.

Figure 1.

Hydroxyurea therapy produced consistent reductions in WBC and ANC without improvement in anemia over 17 weeks. (A) Hydroxyurea at 50mg/kg produced a reduced white blood cell count compared to vehicle treated sickle cell mice. (B) Hydroxyurea at 50 mg/kg produced a reduced absolute neutrophil count compared to vehicle treated sickle cell mice. (C and D) Hydroxyurea at 50 mg/kg produced no improvement in anemia compared to vehicle treated sickle cell mice. P value <0.05 is represented by *. (E) Peripheral blood smear from HU treated sickle cell mouse. (F) Peripheral blood smear from vehicle treated mouse.