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. 2010 May 26;31(17):2080–2086. doi: 10.1093/eurheartj/ehq152

Figure 3.

Figure 3

Time-course of 25 published randomized controlled studies (identified by acronyms, if any, or drug and year of publication) in pulmonary arterial hypertension as of May 2010. Colour code identifies the design of the study: monotherapy (black): investigational drug vs. placebo in patients naive for pulmonary arterial hypertension approved drugs. Monotherapy and/or sequential combination (red): investigational drug vs. placebo in patients either naive for, or treated with pulmonary arterial hypertension approved drugs. Upfront combination (light blue): single drug vs. combination of two drugs in patients naive for pulmonary arterial hypertension approved drugs.