Table 2.

Risk of grade III and IV neutropenia with commonly used neoadjuvant and adjuvant regimens

Regimen	Incidence of FN,%	Reference
Adjuvant
FEC100	8.4	[96]
AC → paclitaxel (all dose levels)	3	[25]
FEC100 → docetaxel	11.2	[96]
TAC	17	[97]
TAC + G-CSF	1	[97]
TC×4	5	[98]
A → C → paclitaxel dose-dense + G-CSF	2	[29]
AC → paclitaxel dose-dense + G-CSF	2	[25]
Neoadjuvant
Epirubicin/docetaxel + G-CSF	7.6	[34]
TEX + G-CSF	0	[35]

FN = Febrile neutropenia; G-CSF = granulocyte colony-stimulating factor; FEC100 = 5-FU, epirubcin 100 mg/m², cyclophosphamide; AC = doxorubicin, cyclophosphamide; TAC = docetaxel, doxorubicin, cyclophosphamide; TEX = docetaxel, epirubicin, capecitabine.