Table 3.

Emetogenic potential of commonly used cytotoxics (without prophylaxis)

Substance	Emetogenic potential, %
Cisplatin > 50 mg/m2	> 90 (12–48ha)
Cyclophosphamide > 1,500 mg/m2	> 90 (12–48ha)
Methotrexate > 1,000 mg/m2	60–90
Cyclophosphamide > 750 – < 1,500 mg/m2	60–90
Doxorubicin > 60 mg/m2	60–90
Cyclophosphamide < 750 mg/m2	30–60
Epirubicin < 90 mg/m2	30–60
Docetaxel, paclitaxel	10–30
5-Fluorouracil < 1,000 mg/m2	10–30

^aDelayed nausea and vomiting.