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Algorithm for surveillance of cardiac function in patients on trastuzumab (based on Keefe D [91])
| LVEF | Drop, % | Screening interval | Trastuzumab |
|---|---|---|---|
| ≥ 50% | no drop | 6 months | go |
| ≥ 30% but < 50% | > 10 | 4 weeks | go |
| < 30% | > 20 | 4 weeks | stopa |
| Symptomatic CHF, any LVEF | stop |
LVEF = left ventricular ejection fraction; CHF = congestive heart failure.
Resume trastuzumab when LVEF returns to normal.
