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Cellular distribution of NHERF1 in breast tissues. Cytoplasmic/membranous NHERF1 protein expression ratio evaluated in normal breast tissue, carcinoma in situ, invasive tumor, synchronous metastatic lymph nodes, and metachronous distant metastasis tissues (horizontal bold line in the box marks mean value; ∗∗∗p < 0.0001, ∗∗p < 0.001, ∗p < 0.01, by parametric unpaired t-test).
