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. 2010 Sep;136(3):311–323. doi: 10.1085/jgp.201010455

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© 2010 Gradogna et al.

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Figure 3. — Relaxation kinetics upon fast concentration jumps in outside-out patches. (A) Example recording of a patch held at 60 mV in which [Ca²⁺]_ext was switched from 10 to 1.8 mM, and then back to 10 mM. Finally, the patch was exposed to a solution without Cl⁻ (and without Ca²⁺). The three insets below show the transition regions on an expanded time scale (bar, 500 ms), superimposed with a single-exponential fit (red line). Time constants for the solution exchange (inset c) were on the order of 10 ms. (B) Average time constants (n > 3 patches) for the indicated transitions.