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. 2010 Aug 30;207(9):1825–1833. doi: 10.1084/jem.20100500

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© 2010 Campbell et al.

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Figure 6. — Altered matrix deposition and protease activity in ERβ null (ERβ^−/−) mice. (A and B) Wound collagen content determined by expression of major collagen species (qPCR) and Picro-Sirius staining was reduced in estrogen (E)-treated ERβ^−/− mice. (C) E-treated peritoneal macrophages from ERβ^−/− mice display increased MMP-2 and MMP-9 expression. (D) Via zymography, MMP-9 activity was strongly increased in E-treated ERβ^−/− wounds. Data from two independent experiments are shown as mean ± SEM using cells in triplicate wells (C) or four animals per group (A). (B and D) Representative of at least four animals per group from three independent experiments. (B) “ERβ^−/−+E” image has been auto stitched from two individual images. Bar, 800 µm. Black asterisk, P < 0.05; red asterisk, P < 0.01.