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(A) Proportion of fragmented nuclei against number of intact nuclei for 203 day 6 blastocysts (10). Fragmenting and healthy nuclei were labeled with polynucleotide-specific fluorochromes and counted by using fluorescence microscopy (e.g., ref. 10). (B) Proportion of 994 embryos that have arrested by a given developmental stage. Accumulated retrospective control data from culture studies observing embryo development in vitro to day 6.
