Figure - PMC

Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2010 Sep 1.

Published in final edited form as: Antivir Chem Chemother. 2009 Sep 25;20(1):37–46. doi: 10.3851/IMP782

PK modeling of the experimental data for cyclopropavir (5) after IV bolus injection of prodrug 6 in mice ( observed, predicted). A, Single compartment first order elimination modeling: Logarithmic plot of the average plasma concentration of cyclopropavir (5) vs. time. The straight line is the linear regression fit to the last three data points (1/Y weighting), which was used to estimate the terminal elimination rate constant β. B, Two compartmental analysis. See text for model description.

Inline graphic — PK modeling of the experimental data for cyclopropavir (5) after IV bolus injection of prodrug 6 in mice ( observed, predicted). A, Single compartment first order elimination modeling: Logarithmic plot of the average plasma concentration of cyclopropavir (5) vs. time. The straight line is the linear regression fit to the last three data points (1/Y weighting), which was used to estimate the terminal elimination rate constant β. B, Two compartmental analysis. See text for model description.