. Author manuscript; available in PMC: 2010 Sep 1.

Published in final edited form as: Antivir Chem Chemother. 2009 Sep 25;20(1):37–46. doi: 10.3851/IMP782

Table 4.

Two compartments first order distribution and elimination PK parameters for prodrug (6) after bolus IV dosing in mice.

Parameter	Best Fit	CV%
Volume of main compartment, V, L/kg	0.0753	14.9
Area under the curve, AUC, mg.min/L	97.1	85.6
Rate constant of distribution phase, α, min.⁻¹	0.25	536
Half-life of distribution phase, T_1/2(α), min.	2.73	535
Rate constant of elimination phase, β, min.⁻¹	0.00263	114
Half-life of elimination phase, T_1/2(β), min.	301	114
Intercept (time zero concentration) of distribution phase, C₀ (A), mg/L	36.5	1234
Intercept (time zero concentration) of elimination phase, C₀ (B), mg/L	1.037	12.3
Clearance (Cl), L/min.	0.217	222