Table 6.
Two compartmental analysis of cyclopropavir (5) plasma levels after IV bolus dosing of prodrug (6). See text for model description.
| Parameter | Best Fit | CV% |
|---|---|---|
| Volume of distribution, V, L/kg | 2.61 | 21.0 |
| Area under the curve, AUC, mg.min/L | 874 | 22.3 |
| Input rate constant, K01, min.−1 | 0.21 | 121 |
| Elimination rate constant, K10, min.−1 | 0.0071 | 32.7 |
| Elimination Half-life of T1/2K10, min. | 97 | 32.7 |
| Time of maximum plasma concentration, Tmax, min. | 16.7 | 85.8 |
| Maximum plasma concentration, Cmax, mg/L | 5.52 | 15.0 |
| Clearance (Cl), L/min. | 0.0185 | 22.3 |
a
A complete conversion of the prodrug (6) to cyclopropavir (5) is assumed, which would result in a equivalent dose of cyclopropavir (5) of 16.2 mg/kg.