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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: Antivir Chem Chemother. 2009 Sep 25;20(1):37–46. doi: 10.3851/IMP782

Table 8.

PK parameters of cyclopropavir (5) after oral dosing of prodrug (6).

Parameter Best Fit
Rate constant of oral elimination phase, λz, 1/min. 0.0106
Half-life of oral elimination phase, T1/2λz, min. 65.6
Time of maximum plasma concentration, Tmax, min. ≤ 20
Maximum plasma concentration, Cmax, mg/L ≥ 15.7
Volume of distribution based on the terminal phase, Vz, L 2.52
Area under the curve at infinity, AUC∞, mg.min/L 1845
Total body clearance (Cl), L/min. 0.0267
Oral bioavailability, % 95.3
a

In this analysis, a complete conversion of the bioavailable prodrug (6) to cyclopropavir (5) was assumed, which would result in a dose equivalent to 32.4 mg/kg of cyclopropavir (5).