Table 1.
Proportion of times the number of events required to provide identical power to detect a statistically significant result is greater for a treatment by marker interaction design (design 1) than for a marker-based strategy design (design 2)
| Scenarios | Proportion of times number of events for design 1 is greater than for design 2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Marker prevalence | ||||||||||
| Median overall survival | Hazard ratios | 0.1 | 0.2 | 0.3 | 0.4 | 0.5 | 0.6 | 0.7 | 0.8 | 0.9 |
|
mB+ > mA+; mA− ≈ mB− |
[1.2, 1.5]; [0.9, 1.1] |
0.21 | 0.33 | 0.47 | 0.59 | 0.69 | 0.79 | 0.87 | 0.93 | 0.98 |
|
mB+ > mA+; mA− > mB− |
[1.2, 1.5]; [0.67, 0.83] |
0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| mB+ > mA+; mA− ≫ mB− |
[1.2, 1.5]; [0.33, 0.67] |
0.50 | 0.40 | 0.31 | 0.22 | 0.14 | 0.07 | 0.03 | 0.01 | 0.00 |
|
mB+ ≫ mA+; mA− ≈ mB− |
[1.5, 3.0]; [0.9, 1.1] |
0.35 | 0.61 | 0.77 | 0.87 | 0.93 | 0.97 | 0.99 | 1.00 | 1.00 |
|
mB+ ≫ mA+; mA− > mB− |
[1.5, 3.0]; [0.67, 0.83] |
0.00 | 0.01 | 0.03 | 0.06 | 0.13 | 0.21 | 0.30 | 0.41 | 0.51 |
|
mB+ ≫ mA+; mA− ≫ mB− |
[1.5, 3.0]; [0.33, 0.67] |
0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |