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Cytoplasmic expression of HER-2 (A-B) and E-cadherin (C-D). Human breast tissue sections from four different cases were double immunostained for SMA (red) and E-cadherin or HER-2 (black). Circles identify elevated cytoplasmic expression of HER-2 and E-cadherin exclusively or preferentially in budding cell projections overlying focally disrupted tumor capsules.
